HEAD & SHOULDERS CLASSIC CLEAN 2-IN-1
Head & Shoulders Classic Clean 2-in-1 is a pyrithione zinc 1% anti-dandruff shampoo and conditioner in one bottle, formulated to control flaking and itching associated with dandruff while cleansing and conditioning hair in a single step . The Microbiome Balance formula targets the root cause of dandruff by maintaining a healthy scalp pH and microbiome, releasing protective ingredients into pores to prevent stubborn dandruff from returning with regular use . Clinically proven to provide up to 100% visible flake control, the pH-balanced, dermatologically tested formula is gentle enough for daily use on all hair types, including colour-treated hair . Leaves hair fresh, clean, and manageable without heavy residue . For external use only. Avoid contact with eyes. If condition worsens or does not improve, consult a doctor. Keep out of reach of children.
HEAD & SHOULDERS CLASSIC CLEAN 2-IN-1
PRIMARY USES
1. Dandruff Protection with Convenient 2-in-1 Cleansing and Conditioning
Primary Use: Provides 1% pyrithione zinc anti-dandruff efficacy combined with conditioning agents in a convenient 2-in-1 formula, controlling flaking and itching associated with dandruff while cleansing and conditioning hair in one step .
How it helps: For the dermatologist and primary care physician, patient compliance with anti-dandruff regimens improves when daily routines are simplified. The 2-in-1 formula combines the anti-dandruff power of a shampoo with the conditioning benefits of a separate product, eliminating the need for an additional step in the shower. The classic clean formula leaves hair fresh, clean, and manageable without weighing it down, making it suitable for everyday use. For the patient, this means effective dandruff control in a convenient, time-saving format that fits seamlessly into their daily routine.
2. Clinically Proven Flake Protection with Microbiome Balance Technology
Primary Use: Clinically proven to provide up to 100% visible flake control with regular use, the Microbiome Balance formula targets the root cause of dandruff by maintaining a healthy scalp pH and microbiome balance, releasing protective ingredients that penetrate deep into pores to prevent stubborn dandruff from returning .
How it helps: For the healthcare professional, scalp microbiome imbalance is central to dandruff pathogenesis and recurrence. The Classic Clean 2-in-1 formulation works against both visible and invisible dandruff by maintaining a healthy pH and scalp microbiome, addressing the underlying condition while the conditioning agents leave hair clean and soft . The formula releases protective ingredients that go into the pores to prevent stubborn dandruff from coming back with regular use . For the patient, this means progressive improvement with each wash—scalp health improves, dandruff recurrence is prevented, and hair remains manageable.
3. Balanced, Dermatologically Tested Formula for All Hair Types
Primary Use: Dermatologically tested, pH-balanced formula that is clinically proven to be effective while remaining gentle enough for daily use on all hair types, including normal, oily, and dry hair, and suitable for colour-treated and chemically treated hair .
How it helps: For the general practitioner and patient, selecting an anti-dandruff product that won’t damage hair quality or cause irritation is essential for long-term adherence. The Classic Clean 2-in-1 formula is specifically designed to be gentle on both scalp and hair, with a pH-balanced composition that maintains the skin’s natural protective barrier . It is safe for daily use across all hair types, including colour-treated hair, ensuring that dandruff management does not compromise hair aesthetics or health . For the patient, this means a single, reliable product that treats their dandruff without forcing trade-offs in hair appearance or style.
4. Convenient 2-in-1 Format for Simplified Hair Care Routines
Primary Use: Combines shampoo and conditioner in one bottle, providing superior dandruff protection and clean, fresh-smelling hair without the need for separate conditioning products, saving time and simplifying daily routines .
How it helps: For the busy patient and dermatologist, streamlining hair care routines improves adherence to anti-dandruff regimens. The 2-in-1 variant delivers the same pyrithione zinc 1% active ingredient while also conditioning the hair, reducing the number of steps in the patient’s shower routine . The classic clean fragrance leaves hair smelling fresh and clean, with no heavy residue or build-up . For the patient, this means a single, convenient product that treats dandruff effectively while leaving hair feeling clean, soft, and manageable.
SECONDARY USES
1. Management of seborrheic dermatitis of the scalp: For patients with mild to moderate seborrheic dermatitis, the 1% pyrithione zinc formulation helps control the inflammatory scaling and itching characteristic of this chronic condition, with the 2-in-1 format providing added convenience for daily use .
2. Prevention of dandruff recurrence in maintenance phase: For patients who have successfully cleared active dandruff, using Classic Clean 2-in-1 regularly helps maintain scalp health and prevent relapse, with the conditioning formula ensuring hair remains manageable .
3. Family dandruff management across different hair types: The gentle, pH-balanced formula is suitable for men, women, and teenagers with all hair types, providing consistent dandruff control across different household members with a single product .
4. Daily use for patients seeking simplified hair care routines: For patients who prefer a streamlined shower routine, the 2-in-1 format eliminates the need for separate conditioner, saving time while maintaining effective dandruff control .
5. Colour-treated hair maintenance: The gentle, pH-balanced formula is safe for colour-treated hair, allowing patients who dye their hair to maintain effective dandruff control without accelerating colour fade .
1. BASIC IDENTIFICATION ATTRIBUTES
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Device Type: Over-the-counter (OTC) topical anti-dandruff shampoo and conditioner; non-prescription medication
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Brand: Head & Shoulders
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Designation: Classic Clean 2-in-1, Classic Clean 2in1 Shampoo + Conditioner
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Active Ingredient: Pyrithione zinc 1% w/v
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Therapeutic Classification: Anti-dandruff / Antifungal (OTC monograph part 358H)
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Product Type: 2-in-1 (shampoo + conditioner combined)
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Available Sizes: 400mL, 700mL, 950mL, 1180mL (varies by region)
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Formulation: Classic Clean conditioning formula
2. TECHNICAL & PERFORMANCE PROPERTIES
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Active Ingredient Concentration: 1 gram pyrithione zinc per 100 mL
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Mechanism of Action: Pyrithione zinc exhibits antifungal activity against Malassezia species, inhibiting yeast growth and reducing inflammatory response, thereby controlling flaking, scaling, and pruritus associated with dandruff and seborrheic dermatitis
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Clinical Efficacy: Up to 100% visible flake protection with regular use; clinically proven
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Microbiome Technology: Microbiome Balance formula targets root cause by maintaining healthy pH and scalp microbiome balance; releases protective ingredients into pores to prevent stubborn dandruff from returning
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Dermatological Testing: Dermatologically tested; pH-balanced
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Fragrance: Classic Clean fresh scent
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Consistency: Liquid shampoo/conditioner (2-in-1)
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Inactive Ingredients: Water, sodium laureth sulfate, sodium lauryl sulfate, cocamidopropyl betaine, sodium chloride, glycol distearate, zinc carbonate, dimethicone, fragrance, sodium benzoate, guar hydroxypropyltrimonium chloride, sodium xylenesulfonate, magnesium carbonate hydroxide, methylchloroisothiazolinone, methylisothiazolinone, sodium hydroxide
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Preservatives: Methylchloroisothiazolinone, methylisothiazolinone, sodium benzoate
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Shelf Life: Not specified; typical for OTC shampoo products when stored properly
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Allergen Information: Contains fragrance; may contain known allergens as fragrance components
3. PHYSICAL & OPERATIONAL PROPERTIES
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Physical Form: Viscous liquid; opaque; pearlescent white appearance
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Route of Administration: Topical (scalp and hair)
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Preparation: Shake bottle before use
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Application Instructions: Wet hair thoroughly. Massage shampoo onto scalp, working into a lather. Rinse thoroughly. Repeat if desired
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Frequency of Use: For best results, use at least twice weekly. For maximum dandruff control, use every time you shampoo
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Treatment Duration: Use regularly as directed; improvement typically visible within 2 weeks of consistent use. Continued use prevents recurrence
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Storage Conditions: Store in a cool, dry place. Keep bottle tightly closed when not in use. Avoid extreme temperatures
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Portion Size: Approximately one to two tablespoons per wash (depends on hair length and thickness)
4. SAFETY & COMPLIANCE ATTRIBUTES
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OTC Monograph Status: Approved under FDA OTC Monograph Final Part 358H for anti-dandruff use
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Indications: Helps prevent recurrence of flaking and itching associated with dandruff
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External Use Only: For topical use on scalp and hair only. Not for ingestion
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Eye Contact Warning: Avoid contact with eyes. If contact occurs, rinse eyes thoroughly with water
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When to Stop Use: Discontinue if condition worsens or does not improve after regular use as directed. Consult a doctor
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Paediatric Safety: Keep this and all drugs out of reach of children
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Ingestion Warning: If swallowed, get medical help or contact a Poison Control Center right away
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Quality Assurance: Manufactured by The Procter & Gamble Manufacturing Company
1. SAFETY PRECAUTIONS
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For external use only: This product is formulated for topical application to scalp and hair. Do not ingest. If swallowed, contact a Poison Control Center immediately.
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Avoid eye contact: Pyrithione zinc can cause eye irritation. If shampoo enters eyes, rinse immediately and thoroughly with water. If irritation persists, seek medical advice.
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Discontinue if irritation develops or condition worsens: While generally well-tolerated, some individuals may experience scalp irritation, dryness, or allergic contact dermatitis. Discontinue use if condition worsens or does not improve after regular use as directed.
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Keep out of reach of children: Product contains active pharmaceutical ingredient. Store in a location where young children cannot access it to prevent accidental ingestion or misuse.
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Appropriate use duration: For dandruff management, regular use is required for maintenance. Improvement typically occurs after 2 weeks of regular use.
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Do not use on broken or irritated scalp: Avoid applying to areas of the scalp that are actively bleeding, oozing, or showing signs of infection. Seek medical advice for severe scalp conditions.
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Not a treatment for systemic fungal infections: This product is intended for topical management of dandruff and seborrheic dermatitis of the scalp only.
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Pregnancy and lactation: Pyrithione zinc 1% shampoo is generally considered safe for use during pregnancy and breastfeeding when used as directed. However, patients should consult their healthcare provider if concerned.
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Proper disposal: Dispose of empty bottle in household waste.
2. FIRST AID MEASURES
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Eye contact: If shampoo enters eyes, rinse immediately with plenty of lukewarm water for at least 15 minutes. Hold eyelids open during rinsing. If irritation persists, seek medical attention.
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Ingestion: If swallowed, do not induce vomiting. Rinse mouth with water. Contact a Poison Control Center immediately or seek emergency medical attention.
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Skin irritation (mild): Discontinue product use. Rinse affected area thoroughly with lukewarm water. If irritation persists beyond 48 hours, consult a healthcare professional.
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Allergic contact dermatitis (rash, itching, redness): Discontinue use immediately. Wash scalp thoroughly with water. Consult a dermatologist if symptoms persist.
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Accidental ingestion by child: Call Poison Control Center immediately (1-800-222-1222 in US) or seek emergency medical care.
3. FIRE FIGHTING MEASURES
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Flammability: Shampoo is water-based and not considered flammable. Plastic packaging may burn if exposed to open flame.
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Extinguishing Media: Use water spray, foam, dry chemical powder, or carbon dioxide (COâ‚‚).
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Fire Response: For small fires involving packaging, use appropriate extinguisher. For large fires, evacuate area. Firefighters should wear self-contained breathing apparatus (SCBA) for fires involving burning plastics.
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